2013.09 – 2017.06 China University of Mining and Technology, Bachelor of Science.
2017.06 – 2019.04 Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Assistant.
2019.04 – 2024.12 Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences; Cixi Institute of Biomedical Engineering, Intern Researcher.
2025.01 – Present Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences; Cixi Institute of Biomedical Engineering, Engineer.
Research Focus:
Total synthesis of near-infrared fluorescent molecular probes.
Application of near-infrared fluorescent molecular probes in tumor imaging.
Contact: yuanbo@nimte.ac.cn
Research Projects and Talent Program Participation:
National Natural Science Foundation of China (General Program), "Study on Y1 Ligand Multimodal Molecular Probe for Enhanced Diagnosis and Treatment via In Situ Self-Assembly in Glioma", 81871411, 2019.01-2022.12, Ongoing, 570,000 CNY.
National Key R&D Program of China "Precision Medicine Initiative", "Development of Molecular Imaging Probes with High Specificity and High Biosecurity for Esophageal Cancer", 2018YFC0910600, 2018.07-2020.12, Ongoing, 6,080,000 CNY.
Preclinical Research on Targeted Therapeutics for Triple-Negative Breast Cancer Based on the Novel Target Neuropeptide Y1 Receptor, Zhejiang Provincial Key R&D Program, 3,000,000 CNY, Participant, 2020-2023.
Development of Isotope-Targeted Pharmaceutical Probes, Advanced Energy Science and Technology Guangdong Laboratory, 45,000,000 CNY, Participant, 2020.09-2023.09.
Selected Publications:
Zhenqi Jiang (#), Bo Yuan (#), Nianxiang Qiu, Yinjie Wang, Li Sun, Zhenni Wei, Yanyin Li, Jianjun Zheng, Yinhua Jin, Yong Li, Shiyu Du, Juan Li (), Aiguo Wu (). Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy. Nano-Micro Letters, 2019, 11, 61. (Co-first author)
Jiang Zhenqi, Yuan Bo, Wang Yinjie, Wei Zhenni, Sun Shan, Akakuru Ozioma Udochukwu, Li Yong, Li Juan (), Wu Aiguo () Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy, Nano Today, 2020, 34: 10.
Jiang, Zhenqi, Li, Yanying, Wei, Zhenni, Yuan, Bo, Wang, Yinjie, Akakuru, Ozioma Udochukwu, Li, Yong, Li, Juan, Wu, Aiguo, Pressure-induced amorphous zeolitic imidazole frameworks with reduced toxicity and increased tumor accumulation improves therapeutic efficacy In vivo, Bioactive Materials, 2021, 6(3): 740-748.
Pan, Chunshu, Lin, Junjie, Zheng, Jianjun, Liu, Chuang, Yuan, Bo, Akakuru, Ozioma Udochukwu, Zubair Iqbal, M., Fang, Qianlan, Hu, Jiapeng, Chen, Jia, Lin, Jie, Dai, Qi, Guo, Xiuyu, Li, Xuehua, Chen, Tianxiang, Wu, Aiguo, Jin, Yinhua, An intelligent T-1-T-2 switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques dagger, Nanoscale, 2021, 13(13): 6461-6474.
Lin, Jie, Yu, Jian, Akakuru, Ozioma Udochukwu, Wang, Xiaotian, Yuan, Bo, Chen, Tianxiang, Guo, Lin, Wu, Aiguo, Low temperature-boosted high efficiency photo-induced charge transfer for remarkable SERS activity of ZnO nanosheets, Chemical Science, 2020, 11(35): 9414-9420.
Wei, Zhenni, Jiang, Zhenqi, Pan, Chunshu, Xia, Jianbi, Xu, Kaiwei, Xue, Ting, Yuan, Bo, Akakuru, Ozioma Udochukwu, Zhu, Chengjie, Zhang, Guilong, Mao, Zheng, Qiu, Xiaozhong, Wu, Aiguo, Shen, Zheyu, Ten-Gram-Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis, Small, 2020, 16(11).
Yinjie Wang (#), Zhenqi Jiang (#), Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Yang, Juan Li (), Aiguo Wu (), Y1 receptor ligand synergized with P-glycoprotein inhibitor improves therapeutic efficacy of multidrug resistant breast cancer，Biomaterials Science, 2019, 7(11): 4748-4757.
Zhenqi Jiang (#), Yinjie Wang (#), Li Sun, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Li, Juan Li (), Aiguo Wu (), Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo, Biomaterials, 2019, 197: 41-50.
Nosike Elvis Ikechukwu, Jiang Zhenqi, Miao Lijing, Akakuru Ozioma Udochukwu, Yuan Bo, Wu Shasha, Zhang Yuenan, Zhang Yujie (), Wu Aiguo (), A novel hybrid nanoadsorbent for effective Hg2+ adsorption based on zeolitic imidazolate framework (ZIF-90) assembled onto poly acrylic acid capped Fe3O4 nanoparticles and cysteine, Journal of Hazardous Materials, 2020, 392: 10.
Ozioma Udochukwu Akakuru, M. Zubair Iqbal, Chuang Liu, Jie Xing, Zhenni Wei, Zhenqi Jiang, Qianlan Fang, Bo Yuan, Elvis Ikechukwu Nosike, Jianbi Xia, Yinhua Jin, Jianjun Zheng, Aiguo Wu, Self-assembled, biocompatible and biodegradable TEMPO-conjugated nanoparticles enable folate-targeted tumor magnetic resonance imaging, Applied Materials Today, 2019, 18: 12.
Patent Applications:
Invention Patent, Juan Li, Bo Yuan, Zhenqi Jiang, Aiguo Wu, "Preparation Method of a Heptamethine Indocyanine Dye and Use Thereof", Application Date: 2019/3/8, CN201910176083.2
Invention Patent, Juan Li, Bo Yuan, Zhenqi Jiang, Aiguo Wu, "A Heptamethine Hydroxyindole Cyanine Dye, Its Synthesis Method and Application", Application Date: 2019/3/8, CN201910175653.6
Invention Patent, Juan Li, Bo Yuan, Aiguo Wu, Zhenqi Jiang, "A Heptamethine Sulfonic Acid Indocyanine Dye, Its Preparation Method and Use", Application Date: 2019/3/8, CN201910175646.6
Invention Patent, Aiguo Wu, Zhenqi Jiang, Bo Yuan, Juan Li, "Preparation Method and Application of a Heptamethine Benzoindole Cyanine Dye", Application Date: 2019/3/8, CN201910175640.9
Invention Patent, Aiguo Wu, Zhenqi Jiang, Bo Yuan, Juan Li, "A Heptamethine Carboxyindole Cyanine Dye and Its Preparation Method and Application", Application Date: 2019/3/8, CN201910176052.7
Invention Patent, Aiguo Wu, Zhenqi Jiang, Bo Yuan, Juan Li, "A Heptamethine Nitroindole Cyanine Dye and Preparation Method and Use Thereof", Application Date: 2019/3/8, CN201910175647.0
Invention Patent, Juan Li, Bo Yuan, Zhenqi Jiang, Aiguo Wu, Yinjie Wang, "A Heptamethine Benzoindole Cyanine Dye and Its Preparation Method and Application", Application Date: 2017/11/17, CN201711147058.9
Invention Patent, Aiguo Wu, Zhenqi Jiang, Bo Yuan, Juan Li, Yinjie Wang, "Preparation Method of a Heptamethine Benzoindole Cyanine Dye", Application Date: 2017/11/17, CN201711147066.3
Invention Patent, Aiguo Wu, Zhenqi Jiang, Juan Li, Yinjie Wang, Bo Yuan, Lingchao Xiang, Yanying Li, "Preparation Method of Zeolitic Imidazolate Framework Material", Application Date: 2018/1/4, CN201810007681.2
Invention Patent, Juan Li, Zhenqi Jiang, Aiguo Wu, Yinjie Wang, Bo Yuan, Qianlan Fang, Yanying Li, "An Anticancer Drug Complex and Its Preparation Method and Application", Application Date: 2017/11/27, CN201711209793.8
Invention Patent, Aiguo Wu, Yinjie Wang, Juan Li, Zhenqi Jiang, Bo Yuan, Lingchao Xiang, Yanying Li, "Polypeptide Complex and Drug-Loaded Nanoparticles, Their Preparation Methods, Pharmaceutical Composition and Application", Application Date: 2018/05/28, CN201810520549.1
Invention Patent, Juan Li, Aiguo Wu, Zhenqi Jiang, Yuchen Tian, Yinjie Wang, Lingchao Xiang, Bo Yuan, "A Nanocomposite Micelle and Its Preparation Method and Application", Application Date: 2018/4/4, CN201810300478.4