Education Background​

2009.09 - 2013.06: Hohai University, Materials Science and Engineering, Bachelor's Degree in Engineering​

2013.09 - 2018.06: Shanghai Institute of Ceramics, Chinese Academy of Sciences (CAS), Materials Science, Doctor's Degree in Engineering​

Work Experience​

2018.07 - 2021.01: Ningbo Huamei Hospital, University of Chinese Academy of Sciences, Assistant Researcher​

2018.09 - 2020.11: Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences (CAS), Postdoctoral Fellow​

2021.02 - 2021.06: Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences (CAS), Guest Assistant Researcher​

2021.07 - Present: Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences (CAS), Associate Researcher​

Academic & Research Achievements​

Mainly engages in the research on the application of nanobiomaterials in the diagnosis and treatment of bacterial infectious diseases.​

In the past 5 years, has published a total of 14 academic papers, including 8 papers as first author / co-first author; participated in compiling 2 English monographs; applied for 5 national invention patents (2 authorized);​

As principal investigator (PI), has hosted 1 Youth Science Fund Project of the National Natural Science Foundation of China, 1 Exploration Project of the Natural Science Foundation of Zhejiang Province, 1 Preferred Funding for Postdoctoral Researchers of Zhejiang Province, and 1 Natural Science Foundation of Ningbo City; as a core member, has participated in 1 Class C Innovation Team of Ningbo "3315 Plan" and 1 Major Special Project of Ningbo "Science and Technology Innovation 2025".​

Research Directions​

Bacteria-targeted nanomaterials​

Antibacterial materials​

Contact Information​

Tel: 0574-86685513​

E-mail: xuchen@nimte.ac.cn

Representative Work

1. Chen Xu, Zihou Li, Ozioma Udochukwu Akakuru, Chunshu Pan, Ruifen Zou, Jianjun Zheng*, Aiguo Wu*. Maltodextrin-conjugated Gd-based MRI contrast agents for specific diagnosis of bacterial infections. ACS Applied Bio Materials, 2021, 4, 5, 3762–3772.
2. Ozioma U. Akakuru, Chen Xu, Chuang Liu, Zihou Li, Jie Xing, Chunshu Pan, Yanying Li, Elvis I. Nosike, Zhoujing Zhang, Zubair M. Iqbal*, Jianjun Zheng*, and Aiguo Wu* Metal-free organo-theranostic nanosystem with high nitroxide stability and loading for image-guided targeted tumor therapy. ACS Nano, 2021, 15, 2, 3079–3097.
3. Chunshu Pan, Junjie Lin, Jianjun Zheng, Chuang Liu, Bo Yuan, Ozioma Udochukwu Akakuru, M Zubair Iqbal, Qianlan Fang, Jiapeng Hu, Jia Chen, Jie Lin, Qi Dai, Xiuyu Guo, Zihou Li, Tao Zhang, Chen Xu, Xuehua Ma, Tianxiang Chen*, Aiguo Wu*, Yinhua Jin*. An intelligent T₁–T₂ switchable MRI contrast agent for the non-invasive identification of vulnerable atherosclerotic plaques. Nanoscale, 2021, 13, 6461-6474.
4. Chen Xu, Ozioma Udochukwu Akakuru, Xuehua Ma, Jianping Zheng*, Jianjun Zheng*, Aiguo Wu*. Nanoparticle-based wound dressing: recent progress in the detection and therapy of bacterial infections. Bioconjugate Chemistry, 2020; 31(7): 1708-1723.
5. Chen Xu, Ozioma Udochukwu Akakuru, Jianjun Zheng* and Aiguo Wu*, Applications of iron oxide-based magnetic nanoparticles in the diagnosis and treatment of bacterial infections. Frontiers in Bioengineering and Biotechnology, 2019, 7:141.
6. Chen Xu, Bing Ma, Jinliang Peng, Long Gao, Yuhong Xu, Zhiguang Huan* and Jiang Chang*, Tricalcium silicate/graphene oxide bone cement with photothermal properties for tumor ablation. Journal of Materials Chemistry B, 2019,7, 2808~2818.
7. Long Gao, Yanling Zhou, Jinliang Peng, Chen Xu, Qing Xu, Min Xing, Jiang Chang*. A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing. NPG Asia Materials, 2019, 11(1): 1-11.
8. Tiantian Wu#, Chen Xu#, Rong Du, Yang Wen, Jiang Chang, Zhiguang Huan*, Yaqin Zhu*, Effects of silicate-based composite material on the proliferation and mineralization behaviors of human dental pulp cells: An in vitro assessment. Dental Materials Journal, 2018, 37(6): 889~896.
9. Yanling Zhou#, Chen Xu#, Xiaoya Wang, Yuandong Dou, Zhiguang Huan*, Jiang Chang*, Fast setting tricalcium silicate/magnesium phosphate premixed cement for root canal filling. Ceramics International, 2018, 44(3): 3015~3023.
10. Chen Xu#, Xiaoya Wang, Jie Zhou, Zhiguang Huan*, Jiang Chang*, Bioactive tricalcium silicate/alginate composite bone cements with enhanced physicochemical properties. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 2018, 106(1): 237~244.
11. Chen Xu#, Yang Wen#, Yanling Zhou, Yaqin Zhu, Yuandong Dou, Zhiguang Huan*, Jiang Chang*, In vitro self-setting properties, bioactivity, and antibacterial ability of a silicate-based premixed bone cement. International Journal of Applied Ceramic Technology, 2018, 15(2): 460~471.
12. Bing Ma#, Zhiguang Huan#, Chen Xu, Nan Ma, Haibo Zhu, Jipin Zhong, Jiang Chang*, Preparation and in vivo evaluation of a silicate-based composite bone cement. Journal of Biomaterials Applications, 2017, 32(2): 257~264.
13. Zhiguang Huan, Chen Xu, Bing Ma, Jie Zhou*, Jiang Chang*, Substantial enhancement of corrosion resistance and bioactivity of magnesium by incorporating calcium silicate particles. RSC Advances, 2016, 6(53): 47897~47906.

1. Chang J, Xu C, Huan Z G. A Collapse-Resistant Calcium-Silicon-Based Composite Bone Cement, Its Preparation Method and Application. Authorized, 2019.11.19. ZL201510797255.X​​
2. Chang J, Xu C, Huan Z G. A Calcium-Silicon-Based Composite Bone Cement with Photothermal Effect, Its Preparation Method and Application. Authorized, 2021.04.16. ZL201810517797.0​​
3. Xu C, Zheng J J, Wu A G. Magnetic Resonance Imaging Contrast Agent Targeting Gram-Positive Bacteria, Its Preparation and Application. Applied, 2020.03.30. 202010236129.8​​
4. Ren W Z, Wu A G, Xu C. Application of a Reduced Metal Oxide Semiconductor Nanomaterial in Antibacterial Materials. Applied, 2020.06.09. 202010514520.X​​
5. Xu C, Zheng J J, Wu A G. A Broad-Spectrum Bacteria-Targeted Magnetic Resonance Imaging Contrast Agent, Its Preparation Method and Application. Applied, 2020.11.09. 202011237671.1​